A C4N4 Diaminopyrimidine Fluorophore
نویسندگان
چکیده
منابع مشابه
Binding thermodynamics of substituted diaminopyrimidine renin inhibitors.
Renin is an aspartyl protease involved in the production of angiotensin II, a potent vasoconstrictor. Renin inhibitors can prevent blood vessel constriction and therefore could be useful for the treatment of hypertension. High-throughput screening efforts identified a small molecule renin inhibitor with a core substituted diaminopyrimidine ring. Parallel medicinal chemistry efforts based on thi...
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Recent studies have revealed that various derivatives of 2,4-diaminopyrimidine exhibit profound biochemical reactivity. For example, nearly all 2,4-diaminopyrimidines and their condensed ring systems inhibit the growth of LactobaciZZus casei with folic acid (1). 2,4-Diamino&p-chlorophenoxypyrimidine was found to be a potent antimalarial in that it was active against Plasmodium gallinaceum infec...
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We report the structure of clusters of 2,4-diaminopyrimidine with 3,7-dimethylxanthine (theobromine) in the gas phase determined by IR-UV double resonance spectroscopy in both the near-IR and mid-IR regions in combination with ab initio computations. These clusters represent potential alternate nucleobase pairs, geometrically equivalent to guanine-cytosine. We have found the four lowest energy ...
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ژورنال
عنوان ژورنال: Chemistry – A European Journal
سال: 2019
ISSN: 0947-6539,1521-3765
DOI: 10.1002/chem.201900865